The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is
regulated primarily by a fluid resistance to aqueous humor outflow. However, neither the
exact site nor the identity of the normal resistance to aqueous humor outflow has been
established. Whether the site and nature of the increased outflow resistance, which is
associated with open-angle glaucoma, is the same or different from the normal resistance is …