PS-341 (Bortezomib) inhibits proliferation and induces apoptosis of megakaryoblastic MO7-e cells
S Galimberti, M Canestraro, S Pacini, R Fazzi… - Leukemia research, 2008 - Elsevier
PS-341 (Bortezomib) is a dipeptide boronic acid proteasome inhibitor with antitumor activity
that induces apoptosis in different human cancer cell lines. We investigated effects of PS-
341 (Bortezomib) on cell proliferation, cell cycle progression, induction of apoptosis and
differentiation in a megakaryoblastic (MO7-e) cell line. PS-341 was able to retain NF-κB in
the cytoplasm and inhibit cell growth (IC50= 22.5 nM), in a dose/time-dependent way. This
anti-proliferative activity resulted to be lineage-specific, because other leukemic cell lines …
that induces apoptosis in different human cancer cell lines. We investigated effects of PS-
341 (Bortezomib) on cell proliferation, cell cycle progression, induction of apoptosis and
differentiation in a megakaryoblastic (MO7-e) cell line. PS-341 was able to retain NF-κB in
the cytoplasm and inhibit cell growth (IC50= 22.5 nM), in a dose/time-dependent way. This
anti-proliferative activity resulted to be lineage-specific, because other leukemic cell lines …