[HTML][HTML] Epidermal growth factor receptor tyrosine kinase inhibitor–resistant disease
Journal of Clinical Oncology, 2013•ncbi.nlm.nih.gov
Purpose EGFR-mutant lung cancer was first described as a new clinical entity in 2004. Here,
we present an update on new controversies and conclusions regarding the disease.
Methods This article reviews the clinical implications of EGFR mutations in lung cancer with
a focus on epidermal growth factor receptor tyrosine kinase inhibitor resistance. Results The
discovery of EGFR mutations has altered the ways in which we consider and treat non–small-
cell lung cancer (NSCLC). Patients whose metastatic tumors harbor EGFR mutations are …
we present an update on new controversies and conclusions regarding the disease.
Methods This article reviews the clinical implications of EGFR mutations in lung cancer with
a focus on epidermal growth factor receptor tyrosine kinase inhibitor resistance. Results The
discovery of EGFR mutations has altered the ways in which we consider and treat non–small-
cell lung cancer (NSCLC). Patients whose metastatic tumors harbor EGFR mutations are …
Abstract
Purpose
EGFR-mutant lung cancer was first described as a new clinical entity in 2004. Here, we present an update on new controversies and conclusions regarding the disease.
Methods
This article reviews the clinical implications of EGFR mutations in lung cancer with a focus on epidermal growth factor receptor tyrosine kinase inhibitor resistance.
Results
The discovery of EGFR mutations has altered the ways in which we consider and treat non–small-cell lung cancer (NSCLC). Patients whose metastatic tumors harbor EGFR mutations are expected to live longer than 2 years, more than double the previous survival rates for lung cancer.
Conclusion
The information presented in this review can guide practitioners and help them inform their patients about EGFR mutations and their impact on the treatment of NSCLC. Efforts should now concentrate on making EGFR-mutant lung cancer a chronic rather than fatal disease.
ncbi.nlm.nih.gov