Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
JD Wilkinson, EM Williamson - Journal of dermatological science, 2007 - Elsevier
BACKGROUND: Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and
have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of
which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in
human skin and anandamide, an endogenous CB receptor ligand, inhibits epidermal
keratinocyte differentiation. Psoriasis is an inflammatory disease also characterised in part
by epidermal keratinocyte hyper-proliferation. OBJECTIVE: We investigated the plant …
have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of
which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in
human skin and anandamide, an endogenous CB receptor ligand, inhibits epidermal
keratinocyte differentiation. Psoriasis is an inflammatory disease also characterised in part
by epidermal keratinocyte hyper-proliferation. OBJECTIVE: We investigated the plant …