Analyzing autophagy in clinical tissues of lung and vascular diseases
HP Kim, ZH Chen, AMK Choi, SW Ryter - Methods in enzymology, 2009 - Elsevier
Autophagy, a process by which organelles and cellular proteins are encapsulated in double‐
membrane vesicles and subsequently degraded by lysosomes, plays a central role in
cellular and tissue homeostasis. In various model systems, autophagy may be triggered by
nutrient deprivation, oxidative stress, and other insults such as endoplasmic reticulum stress,
hypoxia, and pathogen infection. The role of autophagy in lung physiology and homeostasis,
however, has not been well studied. Even less is known of the role of autophagy in the …
membrane vesicles and subsequently degraded by lysosomes, plays a central role in
cellular and tissue homeostasis. In various model systems, autophagy may be triggered by
nutrient deprivation, oxidative stress, and other insults such as endoplasmic reticulum stress,
hypoxia, and pathogen infection. The role of autophagy in lung physiology and homeostasis,
however, has not been well studied. Even less is known of the role of autophagy in the …