Programmed necrosis: from molecules to health and disease
L Galluzzi, TV Berghe, N Vanlangenakker… - International review of …, 2011 - Elsevier
During the past decade, cell death researchers have witnessed a gradual but deep
conceptual revolution: it has been unequivocally shown that necrosis, which for long had
been considered as a purely accidental cell death mode, can also be induced by finely
regulated signal transduction pathways. In particular, when caspases are inhibited by
pharmacological or genetic means, the ligation of death receptors such as the tumor
necrosis factor receptor 1 (TNFR1) can lead to the assembly of a supramolecular complex …
conceptual revolution: it has been unequivocally shown that necrosis, which for long had
been considered as a purely accidental cell death mode, can also be induced by finely
regulated signal transduction pathways. In particular, when caspases are inhibited by
pharmacological or genetic means, the ligation of death receptors such as the tumor
necrosis factor receptor 1 (TNFR1) can lead to the assembly of a supramolecular complex …