[HTML][HTML] Epigenetic concerns in assisted reproduction: update and critical review of the current literature
Y Shufaro, N Laufer - Fertility and sterility, 2013 - Elsevier
More than 4 million children have been born through the use of human in vitro fertilization
(IVF), a technology that emerged only 35 years ago and is still dynamically evolving. Despite
its very good initial safety profile, reports of increased prevalence of human perinatal
problems and evidence obtained from animal experiments raise concerns that the
occurrence of epigenetic anomalies might be increased as a result of infertility etiologies,
ovarian stimulation, and extracorporeal handling and culture of gametes and embryos. This …
(IVF), a technology that emerged only 35 years ago and is still dynamically evolving. Despite
its very good initial safety profile, reports of increased prevalence of human perinatal
problems and evidence obtained from animal experiments raise concerns that the
occurrence of epigenetic anomalies might be increased as a result of infertility etiologies,
ovarian stimulation, and extracorporeal handling and culture of gametes and embryos. This …