Exosomes are nanometer-sized vesicles, secreted by various cell types, present in
biological fluids that are particularly rich in membrane proteins. Ex vivo analysis of
exosomes may provide biomarker discovery platforms and form non-invasive tools for
disease diagnosis and monitoring. These vesicles have never before been studied in the
context of bladder cancer, a major malignancy of the urological tract. We present the first
proteomics analysis of bladder cancer cell exosomes. Using ultracentrifugation on a sucrose …