Cerebral cystine uptake: a tale of two transporters

GJ McBean - Trends in pharmacological sciences, 2002 - cell.com
GJ McBean
Trends in pharmacological sciences, 2002cell.com
Transport of cystine across the cell membrane is essential for synthesis of the major cellular
antioxidant glutathione. Cystine uptake in the brain occurs by both the Na?-independent xc−
cystine–glutamate exchanger and the X AG− family of high-affinity, Na?-dependent
glutamate transporters. New evidence concerning the role of cystine transport in the defence
against oxidative stress is described.
Abstract
Transport of cystine across the cell membrane is essential for synthesis of the major cellular antioxidant glutathione. Cystine uptake in the brain occurs by both the Na?-independent xc cystine–glutamate exchanger and the XAG family of high-affinity, Na?-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described.
cell.com