RAS oncogenes: weaving a tumorigenic web
Y Pylayeva-Gupta, E Grabocka, D Bar-Sagi - Nature Reviews Cancer, 2011 - nature.com
Y Pylayeva-Gupta, E Grabocka, D Bar-Sagi
Nature Reviews Cancer, 2011•nature.comRAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is
frequently detected in several types of cancer. A wealth of biochemical and genetic studies
indicates that RAS proteins control a complex molecular circuitry that consists of a wide
array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit
their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
surface receptors. Oncogenic activation of these proteins owing to missense mutations is
frequently detected in several types of cancer. A wealth of biochemical and genetic studies
indicates that RAS proteins control a complex molecular circuitry that consists of a wide
array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit
their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
Abstract
RAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
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