IFN-γ production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells
S Zhang, B Saha, K Kodys, G Szabo - Journal of hepatology, 2013 - Elsevier
Background & Aims Interferon-γ (IFN-γ), a cytokine produced by activated natural killer cells
(NK) and T lymphocytes, is an important regulator of innate and adaptive immunity during
hepatitis C virus (HCV) infection. However, the cellular sources and mechanisms of IFN-γ
induction in HCV-infection are not fully understood. Methods We cultured normal human
peripheral blood mononuclear cells (PBMCs) with different populations of immune cells and
JFH-1 HCV-infected HuH7. 5 (JFH-1/HuH7. 5) cells. Results We found that PBMCs …
(NK) and T lymphocytes, is an important regulator of innate and adaptive immunity during
hepatitis C virus (HCV) infection. However, the cellular sources and mechanisms of IFN-γ
induction in HCV-infection are not fully understood. Methods We cultured normal human
peripheral blood mononuclear cells (PBMCs) with different populations of immune cells and
JFH-1 HCV-infected HuH7. 5 (JFH-1/HuH7. 5) cells. Results We found that PBMCs …