Calibrated automated thrombin generation assay was adapted to measure thrombin
generation in platelet rich plasma from mice. Vena cava phlebotomy appeared the best
technique for blood sampling. The concentration-effect curves of tissue factor and platelet
count have been determined. Corn trypsin inhibitor 2μM inhibits contact activation
effectively. Recombinant human thrombomodulin does not inhibit thrombin generation in
mouse plasma but activated protein C (20nM) does. Thrombin generation was dose …