The hemostatic effect of platelets has been well-known since it was first reported by Duke in 1910. 1 The possible role of red blood cells (RBC) in hemostasis was also suggested in that article. Since then, RBC transfusions have been used to stop uremic bleeding. 2 In our previous experience, adequate RBC transfusion had good hemostatic effect in patients with anemia and thrombocytopenia. 3 Thus, the role of RBC on hemostasis seems important, but often unrecognized by most of the physicians. In the report of Blajchman et al, 4 anemic rabbits were found to have significantly longer bleeding time than nonanemic animals with a similar degree of thrombocytopenia, and red cell transfusions were found capable of shortening the bleeding time in thrombocytopenic anemic animals. To our knowledge, there were no solid data to prove the hemostatic effect of RBC in humans. In a prospective study, bleeding time (BT), activated partial thromboplastin time (APTT), and prothrombin time (PT) were detected before and after iron administration in 20 patients with iron deficiency anemia. Eleven were men, with a mean age of 56.5 years (SD 19.1; range, 19 to 82). The mean days between two measurements, before and after iron administration, were 54.2 34.51 days (range, 7 to 128). The daily oral dosage of elemental iron was 100 mg.

Platelet and BT decreased significantly, whereas hemoglobin (Hb), RBC, hematocrit (Hct), and mean cell volume (MCV) increased significantly after iron administration (P. 006,. 01,. 0005,. 0005,. 0005, and. 0005, respectively, paired t-test). The mean shortening of BT after iron administration was 1.48 minutes. Fifteen of the 20 patients (75%) had shortened BT after iron administration. On the other hand, APTT and PT did not change significantly after iron administration (P. 142 and. 500, respectively, paired t-test)(Table 1). In the present study, 20 iron deficiency anemic patients were enrolled to evaluate the influence of increased hematocrit on the BT, APTT, and PT. After iron administration, RBC, Hb, Hct, and MCV increased significantly as expected, whereas platelet decreased significantly (Table 1). BT, but not APTT or PT, significantly shortened. In other words, increase of the RBC could shorten BT despite decreased