Enhanced thrombolysis by a factor XIIIa inhibitor in a rabbit model of femoral artery thrombosis
EM Leidy, AM Stern, PA Friedman, LR Bush - Thrombosis research, 1990 - Elsevier
Factor XIIIa (FXIII a) catalyzes covalent crosslinking reactions of fibrin, affording the clot
additional structural stability and resistance to plasmin-mediated degradation. Thus,
inhibition of FXIIIa may render thrombi more susceptible to tissue-plasminogen activator (t-
PA)-induced thrombolysis in vivo. We therefore examined thrombus weight and time to lysis
in anesthetized rabbits undergoing arterial thrombosis produced by insertion of a copper coil
into the lumen of the right femoral artery. The effects of t-PA alone (started 30 min after coil …
additional structural stability and resistance to plasmin-mediated degradation. Thus,
inhibition of FXIIIa may render thrombi more susceptible to tissue-plasminogen activator (t-
PA)-induced thrombolysis in vivo. We therefore examined thrombus weight and time to lysis
in anesthetized rabbits undergoing arterial thrombosis produced by insertion of a copper coil
into the lumen of the right femoral artery. The effects of t-PA alone (started 30 min after coil …