The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism
F Djouadi, JM Brandt, CJ Weinheimer, TC Leone… - … and essential fatty acids, 1999 - Elsevier
The postnatal mammalian heart uses mitochondrial fatty acid oxidation (FAO) as the chief
source of energy to meet the high energy demands necessary for pump function. Flux
through the cardiac FAO pathway is tightly controlled in accordance with energy demands
dictated by diverse physiologic and dietary conditions. In this report, we demonstrate that the
lipid-activated nuclear receptor, peroxisome proliferator-activated receptor α (PPARα),
regulates the expression of several key enzymes involved in cardiac mitochondrial FAO. In …
source of energy to meet the high energy demands necessary for pump function. Flux
through the cardiac FAO pathway is tightly controlled in accordance with energy demands
dictated by diverse physiologic and dietary conditions. In this report, we demonstrate that the
lipid-activated nuclear receptor, peroxisome proliferator-activated receptor α (PPARα),
regulates the expression of several key enzymes involved in cardiac mitochondrial FAO. In …