[HTML][HTML] STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase
H Tokumitsu, H Inuzuka, Y Ishikawa, M Ikeda… - Journal of Biological …, 2002 - ASBMB
STO-609, a selective inhibitor of Ca 2+/calmodulin-dependent protein kinase kinase (CaM-
KK) was synthesized, and its inhibitory properties were investigated both in vitro and in vivo.
STO-609 inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with K i
values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation
activities. Comparison of the inhibitory potency of the compound against various protein
kinases revealed that STO-609 is highly selective for CaM-KK without any significant effect …
KK) was synthesized, and its inhibitory properties were investigated both in vitro and in vivo.
STO-609 inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with K i
values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation
activities. Comparison of the inhibitory potency of the compound against various protein
kinases revealed that STO-609 is highly selective for CaM-KK without any significant effect …