[HTML][HTML] MTMR4 attenuates transforming growth factor β (TGFβ) signaling by dephosphorylating R-Smads in endosomes
J Yu, L Pan, X Qin, H Chen, Y Xu, Y Chen… - Journal of biological …, 2010 - ASBMB
Homeostasis of Smad phosphorylation at its C-terminal SXS motif is essential for
transforming growth factor β (TGFβ) signaling. Whereas it is known that TGFβ signaling can
be terminated by phosphatases, which dephosphorylate R-Smads in the nucleus, it is
unclear whether there are any cytoplasmic phosphatase (s) that can attenuate R-Smad
phosphorylation and nuclear translocation. Here we demonstrate that myotubularin-related
protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DSP) …
transforming growth factor β (TGFβ) signaling. Whereas it is known that TGFβ signaling can
be terminated by phosphatases, which dephosphorylate R-Smads in the nucleus, it is
unclear whether there are any cytoplasmic phosphatase (s) that can attenuate R-Smad
phosphorylation and nuclear translocation. Here we demonstrate that myotubularin-related
protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DSP) …