[HTML][HTML] Hypoxia-activated Smad3-specific Dephosphorylation by PP2A 2
PT Heikkinen, M Nummela, SK Leivonen… - Journal of biological …, 2010 - ASBMB
The transforming growth factor-β (TGF-β) maintains epithelial homeostasis and suppresses
early tumor formation, but paradoxically at later stages of tumor progression, TGF-β
promotes malignancy. TGF-β activates phosphorylation of Smad2 and-3 effectors. Smad2
and-3 are known to have different functions, but differential regulation of their
phosphorylation has not been described. Here we show that upon hypoxia, the TGF-β-
induced phosphorylation of Smad3 was inhibited, although Smad2 remained …
early tumor formation, but paradoxically at later stages of tumor progression, TGF-β
promotes malignancy. TGF-β activates phosphorylation of Smad2 and-3 effectors. Smad2
and-3 are known to have different functions, but differential regulation of their
phosphorylation has not been described. Here we show that upon hypoxia, the TGF-β-
induced phosphorylation of Smad3 was inhibited, although Smad2 remained …