[HTML][HTML] The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions …

SR Trejo, WE Fahl, L Ratner - Journal of Biological Chemistry, 1997 - ASBMB
Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-
oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as
one possible mechanism of cellular transformation by human T-cell leukemia virus type 1. In
previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive
element 1 (TRE1), necessary for transactivation by Tax. We also identified Sp1, Sp3, and
NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate …