[HTML][HTML] Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific
adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely
associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and
substrate recognition into a single multidomain protein, of which the best known are BTB-
BACK-Kelch domain proteins, including KEAP1. Cul3 assembly requires a BTB protein" 3-
box" motif, analogous to the F-box and SOCS box motifs of other Cullin-based E3s. To …
adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely
associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and
substrate recognition into a single multidomain protein, of which the best known are BTB-
BACK-Kelch domain proteins, including KEAP1. Cul3 assembly requires a BTB protein" 3-
box" motif, analogous to the F-box and SOCS box motifs of other Cullin-based E3s. To …