[HTML][HTML] Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes
O Ostrovsky, B Berman, J Gallagher, B Mulloy… - Journal of Biological …, 2002 - ASBMB
Heparan sulfates (HS) play an important role in the control of cell growth and differentiation
by virtue of their ability to modulate the activities of heparin-binding growth factors, an issue
that is particularly well studied for fibroblast growth factors (FGFs). HS/heparin co-ordinate
the interaction of FGFs with their receptors (FGFRs) and are thought to play a critical role in
receptor dimerization. Biochemical and crystallographic studies, conducted mainly with FGF-
2 or FGF-1 and FGF receptors 1 and 2, suggests that an octasaccharide is the minimal …
by virtue of their ability to modulate the activities of heparin-binding growth factors, an issue
that is particularly well studied for fibroblast growth factors (FGFs). HS/heparin co-ordinate
the interaction of FGFs with their receptors (FGFRs) and are thought to play a critical role in
receptor dimerization. Biochemical and crystallographic studies, conducted mainly with FGF-
2 or FGF-1 and FGF receptors 1 and 2, suggests that an octasaccharide is the minimal …