Gene expression profiling of synovial sarcoma: distinct signature of poorly differentiated type
R Nakayama, S Mitani, T Nakagawa… - The American journal …, 2010 - journals.lww.com
Poorly differentiated type synovial sarcoma (PDSS) is a variant of synovial sarcoma
characterized by predominantly round or short-spindled cell morphology. Although
accumulating evidence from clinicopathologic studies suggests a strong association
between this variant of synovial sarcoma and poor prognosis, little has been reported on the
molecular basis of PDSS. To gain insights into the mechanism (s) that underlie the
emergence of PDSS, we analyzed the gene expression profiles of 34 synovial sarcoma …
characterized by predominantly round or short-spindled cell morphology. Although
accumulating evidence from clinicopathologic studies suggests a strong association
between this variant of synovial sarcoma and poor prognosis, little has been reported on the
molecular basis of PDSS. To gain insights into the mechanism (s) that underlie the
emergence of PDSS, we analyzed the gene expression profiles of 34 synovial sarcoma …