[HTML][HTML] A molecular map of mesenchymal tumors
SR Henderson, D Guiliano, N Presneau, S McLean… - Genome biology, 2005 - Springer
SR Henderson, D Guiliano, N Presneau, S McLean, R Frow, S Vujovic, J Anderson…
Genome biology, 2005•SpringerBackground Bone and soft tissue tumors represent a diverse group of neoplasms thought to
derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging
due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over
prognosis and appropriate therapy. Results We have undertaken a broad and
comprehensive study of the gene expression profile of 96 tumors with representatives of all
mesenchymal tissues, including several problem diagnostic groups. Using machine learning …
derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging
due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over
prognosis and appropriate therapy. Results We have undertaken a broad and
comprehensive study of the gene expression profile of 96 tumors with representatives of all
mesenchymal tissues, including several problem diagnostic groups. Using machine learning …
Background
Bone and soft tissue tumors represent a diverse group of neoplasms thought to derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy.
Results
We have undertaken a broad and comprehensive study of the gene expression profile of 96 tumors with representatives of all mesenchymal tissues, including several problem diagnostic groups. Using machine learning methods adapted to this problem we identify molecular fingerprints for most tumors, which are pathognomonic (decisive) and biologically revealing.
Conclusion
We demonstrate the utility of gene expression profiles and machine learning for a complex clinical problem, and identify putative origins for certain mesenchymal tumors.
Springer