[HTML][HTML] Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air …
S Soberanes, D Urich, CM Baker, Z Burgess… - Journal of biological …, 2009 - ASBMB
We have previously reported that airborne particulate matter air pollution (PM) activates the
intrinsic apoptotic pathway in alveolar epithelial cells through a pathway that requires the
mitochondrial generation of reactive oxygen species (ROS) and the activation of p53. We
sought to examine the source of mitochondrial oxidant production and the molecular links
between ROS generation and the activation of p53 in response to PM exposure. Using a
mitochondrially targeted ratiometric sensor (Ro-GFP) in cells lacking mitochondrial DNA (ρ 0 …
intrinsic apoptotic pathway in alveolar epithelial cells through a pathway that requires the
mitochondrial generation of reactive oxygen species (ROS) and the activation of p53. We
sought to examine the source of mitochondrial oxidant production and the molecular links
between ROS generation and the activation of p53 in response to PM exposure. Using a
mitochondrially targeted ratiometric sensor (Ro-GFP) in cells lacking mitochondrial DNA (ρ 0 …