Hypermethylation of estrogen receptor-α gene in atheromatosis patients and its correlation with homocysteine
YS Huang, YF Zhi, SR Wang - Pathophysiology, 2009 - Elsevier
OBJECTIVE: To investigate the aberrant DNA methylation in promoter region of estrogen
receptor α (ERα) in atherosclerosis (As) and the possible involvement of homocysteine (Hcy)
in its pathogenesis. METHODS: The blood samples were collected from 54 patients with As
approved by carotid colorized ultrasound examination and 28 healthy control subjects. The
methylation status of CpG islands in ER-α gene promoter region of genome DNA was
analyzed by nested-methylation-specific PCR (nMSP). tHcy was examined by fluorescent …
receptor α (ERα) in atherosclerosis (As) and the possible involvement of homocysteine (Hcy)
in its pathogenesis. METHODS: The blood samples were collected from 54 patients with As
approved by carotid colorized ultrasound examination and 28 healthy control subjects. The
methylation status of CpG islands in ER-α gene promoter region of genome DNA was
analyzed by nested-methylation-specific PCR (nMSP). tHcy was examined by fluorescent …