[HTML][HTML] Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein …
DT Duong, ME Waltner-Law, R Sears, L Sealy… - Journal of Biological …, 2002 - ASBMB
Hormones regulate glucose homeostasis, in part, by controlling the expression of
gluconeogenic enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK). Insulin
and glucocorticoids reciprocally regulate PEPCK expression primarily at the level of gene
transcription. We demonstrate here that glucocorticoids promote, whereas insulin disrupts,
the association of CREB-binding protein (CBP) and RNA polymerase II with the hepatic
PEPCK gene promoter in vivo. We also show that accessory factors, such as …
gluconeogenic enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK). Insulin
and glucocorticoids reciprocally regulate PEPCK expression primarily at the level of gene
transcription. We demonstrate here that glucocorticoids promote, whereas insulin disrupts,
the association of CREB-binding protein (CBP) and RNA polymerase II with the hepatic
PEPCK gene promoter in vivo. We also show that accessory factors, such as …