Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease
Y Jinsmaa, VR Florang, JN Rees, LM Mexas… - Chemico-biological …, 2011 - Elsevier
Dopamine (DA) undergoes monoamine oxidase catalyzed oxidative deamination to 3, 4-
dihydroxyphenylacetaldehyde (DOPAL), which is metabolized primarily to 3, 4-
dihydroxyphenylacetic acid (DOPAC) via aldehyde dehydrogenase (ALDH). Previous
studies demonstrated DOPAL to be neurotoxic, more so than DA and other metabolites, and
implicated the aldehyde intermediate as a factor in the pathogenesis of Parkinson's disease
(PD). However, the mechanism for generation of DOPAL at aberrant levels and the …
dihydroxyphenylacetaldehyde (DOPAL), which is metabolized primarily to 3, 4-
dihydroxyphenylacetic acid (DOPAC) via aldehyde dehydrogenase (ALDH). Previous
studies demonstrated DOPAL to be neurotoxic, more so than DA and other metabolites, and
implicated the aldehyde intermediate as a factor in the pathogenesis of Parkinson's disease
(PD). However, the mechanism for generation of DOPAL at aberrant levels and the …