The role of oxidative stress in prostate cancer

G Gupta-Elera, AR Garrett, RA Robison… - European Journal of …, 2012 - journals.lww.com
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are not only
byproducts of normal cellular metabolism, but also play important roles in cell signaling.
However, when the levels of ROS and RNS increase, cells are exposed to oxidative
stresses, which activate a variety of mechanisms to allow them to cope with these changes.
Studies have shown that oxidative stress conditions play an important role in both the
initiation and the progression of prostate cancer by regulating molecules such as DNA …