[HTML][HTML] Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells
H Xia, WKC Cheung, SS Ng, X Jiang, S Jiang… - Journal of Biological …, 2012 - ASBMB
miR-124 is a brain-enriched microRNA that plays a crucial role in neural development and
has been shown to be down-regulated in glioma and medulloblastoma, suggesting its
possible involvement in brain tumor progression. Here, we show that miR-124 is down-
regulated in a panel of different grades of glioma tissues and in all of the human glioma cell
lines we examined. By integrated bioinformatics analysis and experimental confirmation, we
identified SNAI2, which is often up-regulated in glioma, as a direct functional target of miR …
has been shown to be down-regulated in glioma and medulloblastoma, suggesting its
possible involvement in brain tumor progression. Here, we show that miR-124 is down-
regulated in a panel of different grades of glioma tissues and in all of the human glioma cell
lines we examined. By integrated bioinformatics analysis and experimental confirmation, we
identified SNAI2, which is often up-regulated in glioma, as a direct functional target of miR …