Creutzfeldt–Jakob disease in a young adult with idiopathic hypopituitarism: possible relation to the administration of cadaveric human growth hormone
TK Koch, BO Berg, SJ De Armond… - New England Journal …, 1985 - Mass Medical Soc
TK Koch, BO Berg, SJ De Armond, RF Gravina
New England Journal of Medicine, 1985•Mass Medical SocCREUTZFELDT—JAKOB disease, a transmissible subacute degeneration of the central
nervous system, is generally considered a disease of older adults. 1 We recently evaluated
a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus
in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received
cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently
testosterone. Case Report The patient, a 20-year-old man, was referred to the University of …
nervous system, is generally considered a disease of older adults. 1 We recently evaluated
a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus
in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received
cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently
testosterone. Case Report The patient, a 20-year-old man, was referred to the University of …
CREUTZFELDT—JAKOB disease, a transmissible subacute degeneration of the central nervous system, is generally considered a disease of older adults.1 We recently evaluated a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently testosterone.
Case Report
The patient, a 20-year-old man, was referred to the University of California, San Francisco, for evaluation of progressive gait instability. His history was complicated by multiple deficiencies of pituitary hormones from infancy, as well as insulin-dependent diabetes mellitus. Hypopituitarism was suggested . . .
The New England Journal Of Medicine