Impact of rpoB mutations on reduced vancomycin susceptibility in Staphylococcus aureus
Y Watanabe, L Cui, Y Katayama, K Kozue… - Journal of Clinical …, 2011 - Am Soc Microbiol
Y Watanabe, L Cui, Y Katayama, K Kozue, K Hiramatsu
Journal of Clinical Microbiology, 2011•Am Soc MicrobiolOf 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%)
possessed a mutation (s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore,
95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus
(MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate
the involvement of an rpoB mutation in VISA phenotype expression.
possessed a mutation (s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore,
95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus
(MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate
the involvement of an rpoB mutation in VISA phenotype expression.
Abstract
Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression.
American Society for Microbiology