Staphylococcus aureus with Heterogeneous Resistance to Vancomycin: Epidemiology, Clinical Significance, and Critical Assessment of Diagnostic Methods

C Liu, HF Chambers - Antimicrobial agents and chemotherapy, 2003 - Am Soc Microbiol
C Liu, HF Chambers
Antimicrobial agents and chemotherapy, 2003Am Soc Microbiol
The first report of Staphylococcus aureus with intermediate-level resistance to vancomycin
(VISA) was from Japan in 1997 (20), raising the threat of incurable staphylococcal infections.
Since then, a number of cases have been reported worldwide, with eight confirmed cases in
the United States as of June 2002 (9, 13). The majority of these cases have occurred in
patients who have had prolonged exposure to vancomycin (13). Furthermore, the majority of
these strains appear to have evolved from methicillin-resistant S. aureus (MRSA) strains …
The first report of Staphylococcus aureus with intermediate-level resistance to vancomycin (VISA) was from Japan in 1997 (20), raising the threat of incurable staphylococcal infections. Since then, a number of cases have been reported worldwide, with eight confirmed cases in the United States as of June 2002 (9, 13). The majority of these cases have occurred in patients who have had prolonged exposure to vancomycin (13). Furthermore, the majority of these strains appear to have evolved from methicillin-resistant S. aureus (MRSA) strains previously infecting the patient, a conclusion that may be drawn from the similarities observed between the pulsed-field gel electrophoresis patterns of the VISA strains and the preexisting MRSA strains (12, 34). Fortunately, since emerging 6 years ago, infection with VISA is still a rare event. However, the phenomenon of vancomycin heteroresistance in S. aureus (hVISA) has been described more frequently in the literature, although the best method to detect hVISA strains and their clinical significance are ill-defined.
American Society for Microbiology