[HTML][HTML] The contentious ontogeny of fibrosis in the kidney
PJ Nelson - Kidney international, 2013 - Elsevier
PJ Nelson
Kidney international, 2013•ElsevierArguably, no cell biology related to the loss of renal function is more debated than the
ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing
most of the excess extracellular matrix in diseased kidneys derive from epithelial cells
versus pericytes resident within the kidney. Reich et al. now contend that circulating bone
marrow–derived fibrocytes independent of monocyte lineages are an important source of
fibrogenic cells recruited to the kidney following injury.
ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing
most of the excess extracellular matrix in diseased kidneys derive from epithelial cells
versus pericytes resident within the kidney. Reich et al. now contend that circulating bone
marrow–derived fibrocytes independent of monocyte lineages are an important source of
fibrogenic cells recruited to the kidney following injury.
Arguably, no cell biology related to the loss of renal function is more debated than the ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing most of the excess extracellular matrix in diseased kidneys derive from epithelial cells versus pericytes resident within the kidney. Reich et al. now contend that circulating bone marrow–derived fibrocytes independent of monocyte lineages are an important source of fibrogenic cells recruited to the kidney following injury.
Elsevier