Microvascular disease, a characteristic of acute and chronic kidney diseases, leads to
rarefaction of peritubular capillaries (PTCs), promoting secondary ischemic injury, which
may be central to disease progression. Bidirectional signaling by EphB4 receptor and
ephrinB2 ligand is critical for angiogenesis during murine development, suggesting that
ephrinB2 reverse signaling may have a role in renal angiogenesis induced by injury or
fibrosis. Here, we found that ephrinB2 reverse signaling is activated in the kidney only after …