Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with< 50 copies/ml HIV-1 RNA

S Baroncelli, CM Galluzzo, MF Pirillo… - Journal of Clinical …, 2009 - Elsevier
BACKGROUND: Recent data have shown that plasma levels of lipopolysaccharide (LPS)
are a quantitative indicator of microbial translocation in HIV infected individuals.
OBJECTIVES: To assess the impact of residual viral replication on plasma LPS in HAART-
treated HIV+ subjects with< 50copies/ml HIV-1 RNA and to evaluate LPS changes during
repeated HAART interruptions not exceeding 2-month duration. STUDY DESIGN: LPS was
measured in 44 HIV+ subjects at T0 (during HAART) and at day 15 of the first and fourth …