[CITATION][C] Perspectives: molecular medicine." Sickle cell anemia, a molecular disease"

BJ Strasser - Science (New York, NY), 1999 - pubmed.ncbi.nlm.nih.gov
Perspectives: molecular medicine. "Sickle cell anemia, a molecular disease" Perspectives:
molecular medicine. "Sickle cell anemia, a molecular disease" Science. 1999 Nov 19;286(5444):1488-90.
doi: 10.1126/science.286.5444.1488. Author BJ Strasser 1 Affiliation 1 Louis-Jeantet
Institute for the History of Medicine, University of Geneva, Geneva, Switzerland. bruno.strasser@medecine.unige.ch
PMID: 10610548 DOI: 10.1126/science.286.5444.1488 No abstract available Publication
types Biography Historical Article Portrait MeSH terms Amino Acid Sequence Anemia …

Sickle cell anemia, a molecular disease

BJ Strasser - Science, 1999 - science.org
Fifty years ago this month, a report appeared that would lay the groundwork for establishing
the field of molecular medicine. In November 1949, America's leading physical chemist,
Linus Pauling [HN1](1901-1994)(see figure below), and his collaborators published their
Science paper entitled “Sickle Cell Anemia, a Molecular Disease”[HN2](1). In this paper,
they showed that hemoglobin [HN3] from patients suffering from sickle cell anemia had a
different electrical charge than that from healthy individuals. This report had a powerful …