[HTML][HTML] Immunity, inflammation, and cancer

SI Grivennikov, FR Greten, M Karin - Cell, 2010 - cell.com
Cell, 2010cell.com
Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation
also affects immune surveillance and responses to therapy. Immune cells that infiltrate
tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the
molecular events that mediate this dialog have been revealed. This review outlines the
principal mechanisms that govern the effects of inflammation and immunity on tumor …
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.
cell.com