The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
AV Krishnan, S Swami, D Feldman - Steroids, 2012 - Elsevier
Calcitriol (1, 25-dihydroxyvitamin D3), the hormonally active form of vitamin D, inhibits the
growth of many malignant cells including breast cancer (BCa) cells. The mechanisms of
calcitriol anticancer actions include cell cycle arrest, stimulation of apoptosis and inhibition
of invasion, metastasis and angiogenesis. In addition we have discovered new pathways of
calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor
positive (ER+) BCa cells. Calcitriol suppresses COX-2 expression and increases that of 15 …
growth of many malignant cells including breast cancer (BCa) cells. The mechanisms of
calcitriol anticancer actions include cell cycle arrest, stimulation of apoptosis and inhibition
of invasion, metastasis and angiogenesis. In addition we have discovered new pathways of
calcitriol action that are especially relevant in inhibiting the growth of estrogen receptor
positive (ER+) BCa cells. Calcitriol suppresses COX-2 expression and increases that of 15 …