[HTML][HTML] Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion∗
EphB receptors provide crucial adhesive and repulsive signals during cell migration and
axon guidance, but it is unclear how they switch between these opposing responses. Here
we provide evidence of an important role for matrix metalloproteinases (MMPs) in repulsive
EphB2 signaling. We found that EphB2 is cleaved by MMPs both in vitro and in vivo, and that
this cleavage is induced by interaction with its ligand ephrin-B2. Our findings demonstrate
that MMP-2/MMP-9-specific inhibition or cleavage-resistant mutations in the ectodomain of …
axon guidance, but it is unclear how they switch between these opposing responses. Here
we provide evidence of an important role for matrix metalloproteinases (MMPs) in repulsive
EphB2 signaling. We found that EphB2 is cleaved by MMPs both in vitro and in vivo, and that
this cleavage is induced by interaction with its ligand ephrin-B2. Our findings demonstrate
that MMP-2/MMP-9-specific inhibition or cleavage-resistant mutations in the ectodomain of …