Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination.
Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE)
is the most common mouse model of MS. Treatments with the sex hormones, estrogens and
androgens, are capable of offering disease protection during EAE and are currently being
used in clinical trials of MS. Beyond endogenous estrogens and androgens, treatments with
selective estrogen receptor modulators (SERMs) for estrogen receptor alpha (ERα) and …