Regulation of endothelial permeability via paracellular and transcellular transport pathways

Y Komarova, AB Malik - Annual review of physiology, 2010 - annualreviews.org
Y Komarova, AB Malik
Annual review of physiology, 2010annualreviews.org
The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall.
Transport of plasma proteins and solutes across the endothelium involves two different
routes: one transcellular, via caveolae-mediated vesicular transport, and the other
paracellular, through interendothelial junctions. The permeability of the endothelial barrier is
an exquisitely regulated process in the resting state and in response to extracellular stimuli …
The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis and transmigration of leukocytes and providing essential nutrients across the vessel wall. Transport of plasma proteins and solutes across the endothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport, and the other paracellular, through interendothelial junctions. The permeability of the endothelial barrier is an exquisitely regulated process in the resting state and in response to extracellular stimuli and mediators. The focus of this review is to provide a comprehensive overview of molecular and signaling mechanisms regulating endothelial barrier permeability with emphasis on the cross-talk between paracellular and transcellular transport pathways.
Annual Reviews