[HTML][HTML] The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity
JYS Tsang, K Ratnasothy, D Li, Y Chen… - American Journal of …, 2011 - Elsevier
CD4+ CD25+ regulatory T cells (T reg cells) are an attractive adoptive cell therapy in
mediating transplantation tolerance. T-cell receptor (TcR) activation is critical for T reg
function, suggesting that the TcR avidity of T reg cells used in therapy may affect the
therapeutic outcome. To address this, we compared the regulatory capacity of T reg lines
expressing TcRs derived from two TcR transgenic mice shown to have the same specificity
but different functional avidities. T reg lines generated from CD4+ CD25+ T cells from …
mediating transplantation tolerance. T-cell receptor (TcR) activation is critical for T reg
function, suggesting that the TcR avidity of T reg cells used in therapy may affect the
therapeutic outcome. To address this, we compared the regulatory capacity of T reg lines
expressing TcRs derived from two TcR transgenic mice shown to have the same specificity
but different functional avidities. T reg lines generated from CD4+ CD25+ T cells from …