Acute kidney injury (AKI) is among the leading causes of morbidity and mortality in
hospitalized patients. Particularly in the perioperative period, the most common cause of AKI
is renal ischemia. At present, therapeutic modalities to prevent or treat AKI are extremely
limited and the search for novel therapeutic interventions for ischemic AKI is an area of
intense investigation. Recent studies implicate the endogenous signaling molecule,
adenosine, in kidney protection from ischemia. As such, enzymatic production of adenosine …