Lens epithelial cells withdraw from the cell cycle to differentiate into secondary fibre cells in
response to vitreal factors. Fibroblast growth factor (FGF) in the vitreous has been shown to
induce lens fibre differentiation in vivo and in vitro through the activation of defined
intracellular signalling, namely via MAPK/ERK1/2 and PI3-K/Akt pathways. To better
understand the role of these growth factor-activated signalling pathways in lens fibre
differentiation, FGF-and vitreous-induced lens fibre differentiation was examined in primary …