[HTML][HTML] LKB1-AMPK axis revisited
F Kottakis, N Bardeesy - Cell research, 2012 - nature.com
F Kottakis, N Bardeesy
Cell research, 2012•nature.comThe LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control
cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to
energy stress via activation of the master regulator of energy homeostasis, AMPK. While
mutational inactivation of LKB1 promotes the development of many types of epithelial
cancer, a recent report in
cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to
energy stress via activation of the master regulator of energy homeostasis, AMPK. While
mutational inactivation of LKB1 promotes the development of many types of epithelial
cancer, a recent report in
The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK. While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer, a recent report in
nature.com