[HTML][HTML] Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of Gβγ and connexin 43 (CX43)
M Sato, Q Jiao, T Honda, R Kurotani, E Toyota… - Journal of biological …, 2009 - ASBMB
Ischemic injury of the heart is associated with activation of multiple signal transduction
systems including the heterotrimeric G-protein system. Here, we report a role of the ischemia-
inducible regulator of Gβγ subunit, AGS8, in survival of cardiomyocytes under hypoxia.
Cultured rat neonatal cardiomyocytes (NCM) were exposed to hypoxia or
hypoxia/reoxygenation following transfection of AGS8siRNA or pcDNA:: AGS8. Hypoxia-
induced apoptosis of NCM was completely blocked by AGS8siRNA, whereas …
systems including the heterotrimeric G-protein system. Here, we report a role of the ischemia-
inducible regulator of Gβγ subunit, AGS8, in survival of cardiomyocytes under hypoxia.
Cultured rat neonatal cardiomyocytes (NCM) were exposed to hypoxia or
hypoxia/reoxygenation following transfection of AGS8siRNA or pcDNA:: AGS8. Hypoxia-
induced apoptosis of NCM was completely blocked by AGS8siRNA, whereas …