[HTML][HTML] Molecular cloning of human plasma membrane phospholipid scramblase: a protein mediating transbilayer movement of plasma membrane phospholipids
Q Zhou, J Zhao, JG Stout, RA Luhm, T Wiedmer… - Journal of Biological …, 1997 - ASBMB
The rapid movement of phospholipids (PL) between plasma membrane leaflets in response
to increased intracellular Ca 2+ is thought to play a key role in expression of platelet
procoagulant activity and in clearance of injured or apoptotic cells. We recently reported
isolation of a∼ 37-kDa protein in erythrocyte membrane that mediates Ca 2+-dependent
movement of PL between membrane leaflets, similar to that observed upon elevation of Ca
2+ in the cytosol (Bassé, F., Stout, JG, Sims, PJ, and Wiedmer, T.(1996) J. Biol. Chem. 271 …
to increased intracellular Ca 2+ is thought to play a key role in expression of platelet
procoagulant activity and in clearance of injured or apoptotic cells. We recently reported
isolation of a∼ 37-kDa protein in erythrocyte membrane that mediates Ca 2+-dependent
movement of PL between membrane leaflets, similar to that observed upon elevation of Ca
2+ in the cytosol (Bassé, F., Stout, JG, Sims, PJ, and Wiedmer, T.(1996) J. Biol. Chem. 271 …