Plasma apolipoprotein L1 levels do not correlate with CKD
LA Bruggeman, JF O'Toole, MD Ross… - Journal of the …, 2014 - journals.lww.com
Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in
individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is
localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is
unclear. We examined associations of plasma APOL1 levels with plasma cytokine levels,
dyslipidemia, and APOL1 genotype in a nested case-control study (n= 270) of HIV-infected
African Americans enrolled in a multicenter prospective observational study. Patients were …
individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is
localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is
unclear. We examined associations of plasma APOL1 levels with plasma cytokine levels,
dyslipidemia, and APOL1 genotype in a nested case-control study (n= 270) of HIV-infected
African Americans enrolled in a multicenter prospective observational study. Patients were …