Risk for ESRD in type 1 diabetes remains high despite renoprotection
ET Rosolowsky, J Skupien, AM Smiles… - Journal of the …, 2011 - journals.lww.com
Historically, patients with type 1 diabetes and macroalbuminuria had high competing risks:
cardiovascular death or renal failure. Here, we assessed these risks in patients receiving
therapies implemented during the last 30 years. Between 1991 and 2004, we enrolled 423
white patients with type 1 diabetes who developed macroalbuminuria (albumin excretion
rate,≥ 300 μg/min). With follow-up for 98% through 2008, ESRD developed in 172 patients
(incidence rate, 5.8/100 person-years), and 29 died without ESRD (mortality rate, 1/100 …
cardiovascular death or renal failure. Here, we assessed these risks in patients receiving
therapies implemented during the last 30 years. Between 1991 and 2004, we enrolled 423
white patients with type 1 diabetes who developed macroalbuminuria (albumin excretion
rate,≥ 300 μg/min). With follow-up for 98% through 2008, ESRD developed in 172 patients
(incidence rate, 5.8/100 person-years), and 29 died without ESRD (mortality rate, 1/100 …