Changes in macrophage phenotype as the immune response evolves
J Lichtnekert, T Kawakami, WC Parks… - Current opinion in …, 2013 - Elsevier
Highlights•Evidence for macrophage reprogramming in vivo.•Macrophage polarization in
acute and chronic inflammation.•Resident macrophage subpopulations are functionally
different.•Therapeutic potential of targeting mononuclear phagocyte system.Mononuclear
phagocytic cells (MPCs), including macrophages and dendritic cells (DCs), are widely
distributed throughout our organs where they perform important homeostatic, surveillance
and regenerative tasks. In response to infection or injury, the composition and number of …
acute and chronic inflammation.•Resident macrophage subpopulations are functionally
different.•Therapeutic potential of targeting mononuclear phagocyte system.Mononuclear
phagocytic cells (MPCs), including macrophages and dendritic cells (DCs), are widely
distributed throughout our organs where they perform important homeostatic, surveillance
and regenerative tasks. In response to infection or injury, the composition and number of …